A Senior Research Scientist position is available immediately in the laboratory of Dr. Joseph B. Shrager, Professor of Cardiothoracic Surgery and Chief of the Division of Thoracic Surgery.

The laboratory as work is focused upon the effects of various disease states and interventions upon the respiratory muscles (e.g., the diaphragm). Recent work in the lab identified dramatic diaphragm muscle fiber atrophy related to mechanical ventilation, and ongoing projects that the successful candidate will be expected to participate in and ultimately direct will include delineating the pathways responsible for this atrophy (working with human tissue) as well as potentially developing animals models to further dissect the mechanisms involved. A clinical trial of an agent designed to avert ventilator-associated atrophy is the ultimate goal. Other projects may include work on respiratory muscle and/or lung repair via regenerative cell or drug therapy.

The position is ideally suited to a scientist who desires to and is capable of functioning largely independently in a leadership role within a laboratory geared towards bridging the clinical-basic research divide. The individual will have the key role in all operational aspects of the lab including animal/IRB protocols, development of new assays, and writing of publications and grants, as the PI has major clinical and administrative commitments. He/she will create protocols, manage and analyze data, and track projects from initiation to completion. He/she will also be primarily responsible for the training and monitoring of a technician and students. The successful candidate will be hard-working and self-motivated, with substantial past research success and publication history, and excellent references. Facility with both protein and nucleic-acid level assays, cell culture, as well as tissue handling, staining, and microscopy is critical. Comfort with animal procedures is also required. Must be capable of modifying/optimizing existing methods and originating new methods. Background in skeletal muscle biology and/or stem cells would be a great advantage. A PhD and at least 5 years of postdoctoral work is required.

The laboratory is well-funded for the next several years. The appointment is for a two year fixed term, renewable indefinitely with excellent performance, 100% FTE.

Stanford University is committed to equal opportunity through affirmative action in employment and we are especially eager to identify minority persons and women with appropriate qualifications.

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